Journal article

Clinical correlates of severe thrombocytopenia from temozolomide in glioblastoma patients

Surein Arulananda, James Lynam, Mun Sem Liew, Morikatsu Wada, Lawrence Cher, Hui K Gan

INTERNAL MEDICINE JOURNAL | WILEY | Published : 2018

Abstract

BACKGROUND/AIM: This study was conducted retrospectively to evaluate rates of thrombocytopenia and their clinical impact during chemo-radiotherapy for glioblastomas and to elucidate associated clinical factors. METHODS: A total of 64 patients who received temozolomide chemotherapy at our institution was included; 35 patients received full-dose chemo-radiotherapy as per the STUPP protocol (Group A), and 9 patients received abbreviated radiotherapy with concurrent chemotherapy (Group B). Twenty patients received temozolomide alone with an intended 12 cycles of therapy for first relapse at least 6 months after completion of adjuvant chemotherapy (Group C). RESULTS: In Group A, 27 of 35 (77%) pa..

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