Relationship between allostatic load and clinical outcomes in youth at ultra-high risk for psychosis in the NEURAPRO study

Maximus Berger; Suzie Lavoie; Patrick D McGorry; Barnaby Nelson; Connie Markulev; Hok-Pan Yuen; Miriam Schaefer; Zoltan Sarnyai; G Paul Amminger

Journal article

Relationship between allostatic load and clinical outcomes in youth at ultra-high risk for psychosis in the NEURAPRO study

Maximus Berger, Suzie Lavoie, Patrick D McGorry, Barnaby Nelson, Connie Markulev, Hok-Pan Yuen, Miriam Schaefer, Zoltan Sarnyai, G Paul Amminger

SCHIZOPHRENIA RESEARCH | ELSEVIER | Published : 2020

DOI: 10.1016/j.schres.2018.10.002

Abstract

Individuals at ultra-high risk (UHR) for psychosis have an elevated risk of developing psychosis and other psychiatric outcomes. Risk biomarkers can assist in delineating individual risk and allow better prediction of longer-term outcomes. The aim of the present study was to examine if allostatic load (AL), a multisystem index of neuroendocrine, cardiovascular, immune and metabolic dysregulation, is associated with clinical outcomes in youth at UHR for psychosis. AL was measured in 106 participants of the NEURAPRO study (n = 70 female, n = 36 male; mean age 17.21, SD 2.37), a multicentre randomized-controlled trial of long-chain omega-3 polyunsaturated fatty acids versus placebo in people at..

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University of Melbourne Researchers

Hok Yuen Author Centre for Youth Mental Health

Maximus Berger Author Centre for Youth Mental Health

Paul Amminger Author Centre for Youth Mental Health

Suzie Lavoie Author Centre for Youth Mental Health

Grants

Awarded by Stanley Medical Research Institute

Funding Acknowledgements

The NEURAPRO RCT was funded by the Stanley Medical Research Institute (grant 07TGF-1102). The present analysiswas supported by a HDRES grant from James Cook University. The funding bodies had no influence on the design of the study or the data analysis.