Journal article

Initial Experience of the Use of 3-Factor Prothrombin Complex Concentrate and Thromboembolic Complications After Cardiac Surgery

India Zweng, Sean Galvin, Ray Robbins, Rinaldo Bellomo, Graeme K Hart, Siven Seevanayagam, George Matalanis

HEART LUNG AND CIRCULATION | ELSEVIER SCIENCE INC | Published : 2019

Abstract

BACKGROUND: 3-factor prothrombin complex concentrate (3F-PCC) may provide a valuable treatment option for coagulopathy in cardiac surgery patients. However, it may expose patients to increased risk of thromboembolic events. Accordingly, we compared the incidence of thromboembolic events between patients exposed to 3F-PCC and those receiving conventional therapy. METHODS: Demographic, operative and postoperative data was obtained in a cohort of consecutive patients exposed to 3F-PCC and a contemporaneous control population. Propensity-score matching was performed for risk adjustment. Unadjusted and adjusted patient demographics and incidence of thromboembolism were compared. RESULTS: Patients..

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