Journal article

A Programmed Anti-Inflammatory Nanoscaffold (PAIN) as a 3D Tool to Understand the Brain Injury Response

Francesca L Maclean, Georgina M Ims, Malcolm K Horne, Richard J Williams, David R Nisbet

ADVANCED MATERIALS | WILEY-V C H VERLAG GMBH | Published : 2018

Abstract

Immunology is the next frontier of nano/biomaterial science research, with the immune system determining the degree of tissue repair. However, the complexity of the inflammatory response represents a significant challenge that is essential to understand for the development of future therapies. Cell-instructive 3D culture environments are critical to improve our understanding of the link between the behavior and morphology of inflammatory cells and to remodel their response to injury. This study has taken two recent high-profile innovations-functional peptide-based hydrogels, and the inclusion of anti-inflammatory agents via coassembly-to make a programmed anti-inflammatory nanoscaffold (PAIN..

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Grants

Awarded by NHMRC


Awarded by ARC discovery project


Awarded by NHMRC Research Fellowship


Awarded by NHMRC Dementia Research Leadership Fellowship


Funding Acknowledgements

R.J.W. and D.R.N. contributed equally to this work. This research was supported by funding from an NHMRC project grant (GNT1144996) and an ARC discovery project (DP130103131). F.L.M. was supported by an Australian Postgraduate Award; M.K.H. was supported by a NHMRC Research Fellowship GNT1020401; D.R.N. was supported by a NHMRC Dementia Research Leadership Fellowship (GNT1135687). Access to the facilities of the Australian National University Centre for Advanced Microscopy (CAM) with funding through the Australian Microscopy and Microanalysis Research Facility (AMMRF) is gratefully acknowledged. Finally, the authors greatly acknowledge Marinova Pty Ltd, Cambridge, Tasmania, Australia for the supply of fucoidan.