Journal article

Acute pulmonary embolism: a concise review of diagnosis and management

Morgan Hepburn-Brown, Jai Darvall, Gary Hammerschlag

INTERNAL MEDICINE JOURNAL | WILEY | Published : 2019

Abstract

An acute pulmonary embolism (aPE) is characterised by occlusion of one or more pulmonary arteries. Physiological disturbance may be minimal, but often cardiac output decreases as the right ventricle attempts to overcome increased afterload. Additionally, ventilation-perfusion mismatches can develop in affected vascular beds, reducing systemic oxygenation. Incidence is reported at 50-75 per 100 000 in Australia and New Zealand, with 30-day mortality rates ranging from 0.5% to over 20%. Incidence is likely to increase with the ageing population, increased survival of patients with comorbidities that are considered risk factors and improving sensitivity of imaging techniques. Use of clinical pr..

View full abstract

University of Melbourne Researchers