FDG PET/CT for assessing tumour response to immunotherapy: Report on the EANM symposium on immune modulation and recent review of the literature
Nicolas Aide, Rodney J Hicks, Christophe Le Tourneau, Stephanie Lheureux, Stefano Fanti, Egesta Lopci
European Journal of Nuclear Medicine and Molecular Imaging | SPRINGER | Published : 2019
This paper follows the immunotherapy symposium held during the European Association of Nuclear Medicine (EANM) 2017 Annual Congress. The biological basis of the immune checkpoint inhibitors and the drugs most frequently used for the treatment of solid tumours are reviewed. The issues of pseudoprogression (frequency, timeline), hyperprogression and immune-related side effects are discussed, as well as their implications for patient management. A review of the recent literature on the use of FDG PET for assessment of immunotherapy is presented, and recommendations are provided for assessing tumour response and reporting immune-related side effects with FDG PET based on published data and exper..View full abstract
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Awarded by AIRC (Associazione Italiana per la Ricerca sul Cancro)
E.L. is the recipient of an ongoing grant from the AIRC (Associazione Italiana per la Ricerca sul Cancro; grant no. 18923). R.J.H. is the recipient of a National Health and Medical Research Council of Australia Practitioner Fellowship.