Defining primary systemic sclerosis heart involvement: A scoping literature review
Laura Ross, David Prior, Susanna Proudman, Alessandra Vacca, Murray Baron, Mandana Nikpour
SEMINARS IN ARTHRITIS AND RHEUMATISM | W B SAUNDERS CO-ELSEVIER INC | Published : 2019
BACKGROUND: Clinically evident primary heart involvement due to systemic sclerosis (SHI) is considered a poor prognostic factor and is a leading cause of systemic sclerosis (SSc) related death. Yet, there remains no consensus definition of SHI and poor understanding of the natural history and risk factors for the development of SHI. METHODS: We performed a scoping literature review of published articles with a primary focus of SHI to capture previously used definitions of SHI and items used to measure SHI. Any factors reported to be associated with an increased risk of SHI were recorded. RESULTS: Of the 2436 records identified in a search of MEDLINE, EMBASE and PubMed databases, 295 were inc..View full abstract
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Awarded by National Health and Medical Research Council of Australia Fellowship
LR is supported by a Musculoskeletal Australia PhD scholarship and an Australian Government Research Training Program Scholarship. MN holds a National Health and Medical Research Council of Australia Fellowship (APP 1126370). This work is supported by a Scleroderma Clinical Trials Consortium (SCTC) Working Group Grant.