Determinants of health-related quality of life in a multinational systemic sclerosis inception cohort.
Kathleen Morrisroe, Marie Hudson, Murray Baron, Jeska de Vries-Bouwstra, Patricia E Carreira, Dirk M Wuttge, Mianbo Wang, Tracy M Frech, Wendy Stevens, Susanna M Proudman, Mandana Nikpour, undefined International Systemic Sclerosis Inception Cohort (INSYNC) collaboration
Clin Exp Rheumatol | Published : 2018
OBJECTIVES: To evaluate health-related quality of life (HRQoL) and its determinants in a systemic sclerosis (SSc) multinational inception cohort. We performed a meta-analysis of data from individual countries, and compared the meta-analysis to individual country results by pooling data from each of the countries. METHODS: SSc patients within 2 years of disease onset were recruited from 5 countries participating in the International Systemic Sclerosis Inception Cohort (INSYNC). Data from each country's database were exported for analysis using a harmonised platform. HRQoL was assessed using the Medical Outcomes Short Form-36 (SF-36). Multivariate linear regression assessed associations betwee..View full abstract