Synergy between nutritional immunity and independent host defenses contributes to the importance of the MntABC manganese transporter during staphylococcus aureus infection

JN Radin; J Zhu; EB Brazel; CA McDevitt; TE Kehl-Fiea

Journal article

Synergy between nutritional immunity and independent host defenses contributes to the importance of the MntABC manganese transporter during staphylococcus aureus infection

JN Radin, J Zhu, EB Brazel, CA McDevitt, TE Kehl-Fiea

Infection and Immunity | AMER SOC MICROBIOLOGY | Published : 2019

DOI: 10.1128/IAI.00642-18

Abstract

During infection, the host utilizes a diverse array of processes to combat invaders, including the restriction of availability of essential nutrients such as manganese. Similarly to many other pathogens, Staphylococcus aureus possesses two manganese importers, MntH and MntABC. Several infection models have revealed a critical role for MntABC during staphylococcal infection. However, culture-based studies have suggested parity between the two transporters when cells are resisting manganese starvation imposed by the manganese binding immune effector calprotectin. In this investigation, initial elemental analysis revealed that MntABC is the primary transporter responsible for obtaining manganes..

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University of Melbourne Researchers

Christopher McDevitt Author

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Grants

Awarded by National Institutes of Health

Funding Acknowledgements

This work was supported by grants from the National Institutes of Health (K22 AI104805 and RO1 AI18880), by a March of Dimes Basil O'Conner award and a Vallee Scholars award to T.E.K.-F., and by grants from the National Health and Medical Research Council (project grants 1122582 and 1140554) and the Australian Research Council (Discovery Project DP170102102 and Future Fellowship FT170100006) to C.A.M. This work does not represent the views of the March of Dimes or the National Institutes of Health.