Cerebral-placental-uterine ratio as novel predictor of late fetal growth restriction: prospective cohort study
TM Macdonald, L Hui, AJ Robinson, KM Dane, AL Middleton, S Tong, SP Walker
ULTRASOUND IN OBSTETRICS & GYNECOLOGY | WILEY | Published : 2019
OBJECTIVE: Fetal growth restriction (FGR) is a major risk factor for stillbirth and most commonly arises from uteroplacental insufficiency. Despite clinical examination and third-trimester fetal biometry, cases of FGR often remain undetected antenatally. Placental insufficiency is known to be associated with altered blood flow resistance in maternal, placental and fetal vessels. The aim of this study was to evaluate the performance of individual and combined Doppler blood flow resistance measurements in the prediction of term small-for-gestational age and FGR. METHODS: This was a prospective study of 347 nulliparous women with a singleton pregnancy at 36 weeks' gestation in which fetal growt..View full abstract
We thank the health information services, birth suite, operating theater, postnatal ward, nursery, university research department and perinatal medicine staff at the Mercy Hospital for Women for their assistance in conducting this study. We thank the philanthropic donors to the Mercy Health Foundation for their generous support. In particular, we also thank Dr Richard Hiscock (MBiostat) for his most valuable statistical advice.