Journal article

Differential effects of chronic 17 beta-oestradiol treatment on rat behaviours relevant to depression

Andrea Gogos, Madeleine McCarthy, Adam J Walker, Madhara Udawela, Andrew Gibbons, Brian Dean, Snezana Kusljic

JOURNAL OF NEUROENDOCRINOLOGY | WILEY | Published : 2018

Abstract

Sex differences are a prominent feature of the pathophysiology of psychiatric disorders, such as major depressive disorder, which affects women at a higher incidence than men. Research suggests that the most potent endogenous oestrogen, 17β-oestradiol, may have therapeutic potential in treating depression. However, preclinical studies have produced mixed results, likely as a result of various methodological factors such as treatment duration. The present study aimed to investigate the effects of ovariectomy and chronic 17β-oestradiol treatment via a s.c. silastic implant on behaviours relevant to depression in adult female Sprague-Dawley rats. Rats were assessed in the forced swim test, sacc..

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