Journal article

In renovascular hypertension, TNF- type-1 receptors in the area postrema mediate increases in cardiac and renal sympathetic nerve activity and blood pressure

Willian S Korim, Khalid Elsaafien, Jeremy R Basser, Anthony Setiadi, Clive N May, Song T Yao

CARDIOVASCULAR RESEARCH | OXFORD UNIV PRESS | Published : 2019

Abstract

AIMS: Neuroinflammation is a common feature in renovascular, obesity-related, and angiotensin II mediated hypertension. There is evidence that increased release of the pro-inflammatory cytokine tumour necrosis factor-α (TNF-α) contributes to the development of the hypertension, but the underlying neural mechanisms are unclear. Here, we investigated whether TNF-α stimulates neurons in the area postrema (AP), a circumventricular organ, to elicit sympathetic excitation, and increases in blood pressure (BP). METHODS AND RESULTS: In rats with renovascular hypertension, AP neurons that expressed TNF-α type-1 receptor (TNFR1) remained constantly activated (expressed c-Fos) and injection of TNFR1 ne..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Australian Research Council Future Fellowship


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council of Australia (GNT 1079680 to S.T.Y.), the High Blood Pressure Research Council of Australia, the Rebecca L Cooper Medical Foundation, the Wade Institute and Ormond College-University of Melbourne (to W.S.K.) and the Victorian Government through the Operational Infrastructure Scheme. K.E. and A.S. are supported by the Australian Government Research Training Program Scholarships. S.T.Y. is supported by an Australian Research Council Future Fellowship (FT170100363).