Journal article
Small volume resuscitation with 20% albumin in intensive care: physiological effects: The SWIPE randomised clinical trial
J Mårtensson, S Bihari, J Bannard-Smith, NJ Glassford, P Lloyd-Donald, L Cioccari, N Luethi, A Tanaka, M Crisman, N Rey de Castro, M Ottochian, A Huang, M Cronhjort, AD Bersten, S Prakash, M Bailey, GM Eastwood, R Bellomo
Intensive Care Medicine | SPRINGER | Published : 2018
Abstract
Purpose: We set out to assess the resuscitation fluid requirements and physiological and clinical responses of intensive care unit (ICU) patients resuscitated with 20% albumin versus 4–5% albumin. Methods: We performed a randomised controlled trial in 321 adult patients requiring fluid resuscitation within 48 h of admission to three ICUs in Australia and the UK. Results: The cumulative volume of resuscitation fluid at 48 h (primary outcome) was lower in the 20% albumin group than in the 4–5% albumin group [median difference − 600 ml, 95% confidence interval (CI) − 800 to − 400; P < 0.001]. The 20% albumin group had lower cumulative fluid balance at 48 h (mean difference − 576 ml, 95% CI − 10..
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Funding Acknowledgements
The Australian and New Zealand Intensive Care Foundation and CSL Behring (UK) funded the study. The SWIPE trial investigators would like to thank Dr Ying Yan Zhu and Dr Jason Musci for their help with obtaining consent from patients and relatives, and Elisha Matheson, Kate Schwartz and Kate Norman from Flinders Medical Centre and Leah Peck and Helen Young from Austin Hospital for their help with data collection.