Journal article

Persistently Elevated Microvascular Resistance Postrecanalization A Clinical Marker of No-Reflow Phenomenon

Felix C Ng, Bronwyn Coulton, Brian Chambers, Vincent Thijs

STROKE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018

Abstract

Background and Purpose- Impaired microvascular reperfusion despite complete recanalization (no-reflow) represents a potential therapeutic target to improve outcomes after recanalization therapies. Although well documented in animal models, this phenomenon has not been demonstrated clinically. We investigated whether transcranial Doppler can detect acute microvascular changes postrecanalization as a biomarker of the no-reflow phenomenon in stroke patients. Methods- Consecutive patients with recanalized (Thrombolysis in Cerebral Infarction grade IIb/III) acute middle cerebral artery occlusion by thrombectomy at a Comprehensive Stroke Centre with a high-volume neurovascular laboratory were retr..

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