Ultra-high-risk paradigm: lessons learnt and new directions
Patrick D McGorry, Cristina Mei
EVIDENCE-BASED MENTAL HEALTH | BMJ PUBLISHING GROUP | Published : 2018
Within the embryonic early psychosis field in the early 1990s, the conceptualisation and definition of an at-risk or ultra-high-risk (UHR) mental state for psychosis was a breakthrough which transformed the clinical and research landscape in psychiatry. Twenty-five years later, we have a new evidence base that has illuminated the neurobiology of the onset phase of psychotic disorder, delivered Cochrane level 1 evidence showing that the onset of full-threshold sustained psychotic disorder can be at least delayed, and is paving the way to a new generation of transdiagnostic research. Here, we document the contribution of the UHR approach to understanding the underlying mechanisms of psychosis ..View full abstract
Awarded by NHMRC Senior Principal Research Fellowship
PDM is supported by an NHMRC Senior Principal Research Fellowship (1060996).