Journal article

Alterations in regional kidney oxygenation during expansion of extracellular fluid volume in conscious healthy sheep

Yugeesh R Lankadeva, Roger G Evans, Junko Kosaka, Lindsea C Booth, Naoya Iguchi, Rinaldo Bellomo, Clive N May

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2018

Abstract

Expansion of extracellular fluid volume with crystalloid solutions is a common medical intervention, but its effects on renal cortical and medullary oxygenation are poorly understood. Therefore, we instrumented sheep under general anesthesia to enable continuous measurement of systemic and renal hemodynamics, global renal oxygen delivery and consumption, and intrarenal tissue perfusion and oxygen tension (Po2) in conscious animals ( n = 7). The effects of three sequential intermittent infusions of 500 ml of compound sodium lactate solution, administered at hourly intervals, were determined. Volume expansion induced transient increases in mean arterial pressure (+7 ± 2%), central venous press..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Heart Foundation of Australia


Funding Acknowledgements

This study was supported by a grant from the National Health and Medical Research Council of Australia (No. 1050672) and by funding from the Victorian Government Operational Infrastructure Support Grant. Y. R. Lankadeva was supported by a Future Leader Postdoctoral Fellowship by the National Heart Foundation of Australia (No. 101853).