Journal article

Generalized polyspike train An EEG biomarker of drug-resistant idiopathic generalized epilepsy

Yanping Sun, Udaya Seneviratne, Piero Perucca, Zhibin Chen, Meng Kee Tan, Terence J O'Brien, Wendyl D'Souza, Patrick Kwan

NEUROLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018

Abstract

OBJECTIVE: To identify clinical and EEG biomarkers of drug resistance in adults with idiopathic generalized epilepsy. METHODS: We conducted a case-control study consisting of a discovery cohort and a replication cohort independently assessed at 2 different centers. In each center, patients with the idiopathic generalized epilepsy phenotype and generalized spike-wave discharges on EEG were classified as drug-resistant or drug-responsive. EEG changes were classified into predefined patterns and compared between the 2 groups in the discovery cohort. Factors associated with drug resistance in multivariable analysis were tested in the replication cohort. RESULTS: The discovery cohort included 85 ..

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Grants

Awarded by Qingdao Municipal Science and Technology Bureau, Qingdao, Shandong, China


Funding Acknowledgements

This study was supported in part by Qingdao Municipal Science and Technology Bureau, Qingdao, Shandong, China (funding number 15-9-2-85-nsh). Dr. Kwan is supported by the MRFF Practitioner Fellowship. Dr. Perucca is supported by the Bridging Postdoctoral Fellowship from Monash University.