Vitamin D supplementation improves waist-to-hip ratio and fasting blood glucose in vitamin D deficient, overweight or obese Asians: A pilot secondary analysis of a randomised controlled trial
David Scott, Aya Mousa, Negar Naderpoor, Maximilian PJ de Courten, Robert Scragg, Barbora de Courten
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2019
Recent trials do not support a role for vitamin D supplementation in prevention or treatment of type 2 diabetes mellitus, although effects may differ in Asian populations. In this pilot secondary analysis of a placebo-controlled randomised trial of overweight or obese individuals with low 25-hydroxyvitamin D (25(OH)D < 50 nmol/L), we examined whether vitamin D supplementation improved insulin sensitivity or body composition in participants of Asian ethnicity. Amongst 65 trial participants, 33 reported being of Asian descent (mean ± SD age 30 ± 7 years; 67% male). Participants were block randomised to receive vitamin D (n = 14; initial bolus dose of 2500 μg cholecalciferol followed by 100 μg ..View full abstract
Awarded by Australian National Health and Medical Research Council (NHMRC)
Awarded by NHMRC RD Wright Biomedical Career Development Fellowship
Awarded by National Heart Foundation Future Leader Fellowship
This work was supported by an Australian National Health and Medical Research Council (NHMRC) (grant number 1047897 to BdC). DS is supported by a NHMRC RD Wright Biomedical Career Development Fellowship (GNT1123014). BdC is supported by a National Heart Foundation Future Leader Fellowship (100864).