Journal article

Anticariogenic efficacy of a saliva biomimetic in head-and-neck cancer patients undergoing radiotherapy

CPC Sim, GD Walker, DJ Manton, YL Soong, JTS Wee, GG Adams, EC Reynolds



BACKGROUND: The aim of this study was to investigate the effect of treatment with the saliva biomimetic, casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and SnF2 /NaF compared with SnF2 /NaF alone on coronal surface caries progression in head-and-neck cancer patients undergoing radiotherapy. METHODS: Twenty-four participants were randomized into two groups. Both groups used 0.4% SnF2 gel and a 0.32% NaF toothpaste; the test group also applied a crème containing 10% CPP-ACP three times daily while the control group used an identical crème without CPP-ACP (placebo). Resting saliva flow rate and saliva fluoride concentrations were determined. Caries status was assessed using ICDASII..

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Funding Acknowledgements

This work was supported by the National Dental Centre Singapore Research Fund/National Medical Research Council Centre Grant and the Australian Government, Department of Industry, Innovation and Science. CPC Sim is a recipient of a Singapore National Medical Research Council Research Training Fellowship. GC Asia (Tokyo, Japan) provided the CPP-ACP and placebo products.