Anticariogenic efficacy of a saliva biomimetic in head-and-neck cancer patients undergoing radiotherapy
CPC Sim, GD Walker, DJ Manton, YL Soong, JTS Wee, GG Adams, EC Reynolds
AUSTRALIAN DENTAL JOURNAL | WILEY | Published : 2019
BACKGROUND: The aim of this study was to investigate the effect of treatment with the saliva biomimetic, casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and SnF2 /NaF compared with SnF2 /NaF alone on coronal surface caries progression in head-and-neck cancer patients undergoing radiotherapy. METHODS: Twenty-four participants were randomized into two groups. Both groups used 0.4% SnF2 gel and a 0.32% NaF toothpaste; the test group also applied a crème containing 10% CPP-ACP three times daily while the control group used an identical crème without CPP-ACP (placebo). Resting saliva flow rate and saliva fluoride concentrations were determined. Caries status was assessed using ICDASII..View full abstract
This work was supported by the National Dental Centre Singapore Research Fund/National Medical Research Council Centre Grant and the Australian Government, Department of Industry, Innovation and Science. CPC Sim is a recipient of a Singapore National Medical Research Council Research Training Fellowship. GC Asia (Tokyo, Japan) provided the CPP-ACP and placebo products.