Journal article

Estimation of annual probabilities of changing disability levels in Australians with relapsing-remitting multiple sclerosis

Hasnat Ahmad, Ingrid van der Mei, Bruce Taylor, Robyn M Lucas, Anne-Louise Ponsonby, Jeannette Lechner-Scott, Keith Dear, Patricia Valery, Philip M Clarke, Steve Simpson, Andrew J Palmer, Terry Dwyer, Leigh Blizzard, Simon Broadley, Trevor Kilpatrick, David Williams, Jeanette Lechner-Scott, Cameron Shaw, Caron Chapman, Alan Coulthard Show all

Multiple Sclerosis Journal | SAGE PUBLICATIONS LTD | Published : 2019

Abstract

BACKGROUND: Transition probabilities are the engine within many health economics decision models. However, the probabilities of progression of disability due to multiple sclerosis (MS) have not previously been estimated in Australia. OBJECTIVES: To estimate annual probabilities of changing disability levels in Australians with relapsing-remitting MS (RRMS). METHODS: Combining data from Ausimmune/Ausimmune Longitudinal (2003-2011) and Tasmanian MS Longitudinal (2002-2005) studies (n = 330), annual transition probabilities were obtained between no/mild (Expanded Disability Status Scale (EDSS) levels 0-3.5), moderate (EDSS 4-6.0) and severe (EDSS 6.5-9.5) disability. RESULTS: From no/mild disab..

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