Journal article

Coffee, tea, and caffeine intake and amyotrophic lateral sclerosis mortality in a pooled analysis of eight prospective cohort studies

J Petimar, E O'Reilly, H-O Adami, PA van den Brandt, J Buring, DR English, DM Freedman, GG Giles, N Hakansson, T Kurth, SC Larsson, K Robien, LJ Schouten, E Weiderpass, A Wolk, SA Smith-Warner

EUROPEAN JOURNAL OF NEUROLOGY | WILEY | Published : 2019

Abstract

BACKGROUND AND PURPOSE: Caffeine is associated with a lower risk of some neurological diseases, but few prospective studies have investigated caffeine intake and risk of amyotrophic lateral sclerosis (ALS) mortality. We therefore determined associations between coffee, tea and caffeine intake, and risk of ALS mortality. METHODS: We conducted pooled analyses of eight international, prospective cohort studies, including 351 565 individuals (120 688 men and 230 877 women). We assessed coffee, tea and caffeine intake using validated food-frequency questionnaires administered at baseline. We used Cox regression to estimate study- and sex-specific risk ratios and 95% confidence intervals (CI) for ..

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