Coffee, tea, and caffeine intake and amyotrophic lateral sclerosis mortality in a pooled analysis of eight prospective cohort studies
J Petimar, E O'Reilly, H-O Adami, PA van den Brandt, J Buring, DR English, DM Freedman, GG Giles, N Hakansson, T Kurth, SC Larsson, K Robien, LJ Schouten, E Weiderpass, A Wolk, SA Smith-Warner
EUROPEAN JOURNAL OF NEUROLOGY | WILEY | Published : 2019
BACKGROUND AND PURPOSE: Caffeine is associated with a lower risk of some neurological diseases, but few prospective studies have investigated caffeine intake and risk of amyotrophic lateral sclerosis (ALS) mortality. We therefore determined associations between coffee, tea and caffeine intake, and risk of ALS mortality. METHODS: We conducted pooled analyses of eight international, prospective cohort studies, including 351 565 individuals (120 688 men and 230 877 women). We assessed coffee, tea and caffeine intake using validated food-frequency questionnaires administered at baseline. We used Cox regression to estimate study- and sex-specific risk ratios and 95% confidence intervals (CI) for ..View full abstract
Awarded by NIH
Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
This work was supported by NIH grant R01-NS072494-01A1 awarded to E.O'R. and T32 HL098048 awarded to J.P. Funding for each cohort is listed in Table S2.