Diffusion MRI abnormalities in adolescent rats given repeated mild traumatic brain injury
Ryan C Wortman, Alicia Meconi, Katie J Neale, Rhys D Brady, Stuart J McDonald, Brian R Christie, David K Wright, Sandy R Shultz
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | WILEY | Published : 2018
Objective: Mild traumatic brain injury (mTBI) is a serious health concern in the adolescent population. Repeated mTBI may result in more pronounced deficits, and has been associated with long-term neurological consequences including neurodegeneration. As such, there is a critical need for the development of objective mTBI biomarkers to help guide medical management. Diffusion-weighted imaging (DWI) is an advanced magnetic resonance imaging (MRI) technique that may detect brain abnormalities after mTBI. Diffusion tensor imaging (DTI) is the most commonly applied DWI method, and initial studies have reported DTI changes in mTBI patients. Furthermore, new DWI methods (e.g., track-weighted imagi..View full abstract
RCW and AM were supported by Canadian Institutes of Health Research graduate fellowships. The studies were funded by grants from NSERC and CFI to BRC, and the Australian NHMRC to SRS.