Journal article

Aetiology of childhood apraxia of speech: A clinical practice update for paediatricians

Angela T Morgan, Richard Webster

JOURNAL OF PAEDIATRICS AND CHILD HEALTH | WILEY | Published : 2018

Abstract

Childhood apraxia of speech (CAS) is a rare disorder of childhood that can leave a watermark of the impacts throughout the lifetime. Since being first described in the 1950s, aetiological insights have been limited. At a neurobiological level, clinical MRI scans fail to reveal overt neural anomalies in individual cases with CAS, although quantitative MRI methods have revealed subtle brain anomalies at a group level. Dramatic insights, however, occurred in the past decade from the discovery of genetic pathways underlying the phenotype. Several single genes and copy number-variant conditions are now associated with CAS either in relative isolation, as in the case of FOXP2 variants, or most typ..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) Centre of Research Excellence


Awarded by NHMRC Project Grant


Awarded by NHMRC Practitioner Fellowship


Funding Acknowledgements

This study was supported by the National Health and Medical Research Council (NHMRC) Centre of Research Excellence (1116976 (to AT Morgan)); NHMRC Project Grant (1127144 (to AT Morgan)) and NHMRC Practitioner Fellowship (1105008 (to AT Morgan)). This work was also supported by the Victorian Government's Operational Infrastructure Support Programme.