Aetiology of childhood apraxia of speech: A clinical practice update for paediatricians
Angela T Morgan, Richard Webster
JOURNAL OF PAEDIATRICS AND CHILD HEALTH | WILEY | Published : 2018
Childhood apraxia of speech (CAS) is a rare disorder of childhood that can leave a watermark of the impacts throughout the lifetime. Since being first described in the 1950s, aetiological insights have been limited. At a neurobiological level, clinical MRI scans fail to reveal overt neural anomalies in individual cases with CAS, although quantitative MRI methods have revealed subtle brain anomalies at a group level. Dramatic insights, however, occurred in the past decade from the discovery of genetic pathways underlying the phenotype. Several single genes and copy number-variant conditions are now associated with CAS either in relative isolation, as in the case of FOXP2 variants, or most typ..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) Centre of Research Excellence
Awarded by NHMRC Project Grant
Awarded by NHMRC Practitioner Fellowship
This study was supported by the National Health and Medical Research Council (NHMRC) Centre of Research Excellence (1116976 (to AT Morgan)); NHMRC Project Grant (1127144 (to AT Morgan)) and NHMRC Practitioner Fellowship (1105008 (to AT Morgan)). This work was also supported by the Victorian Government's Operational Infrastructure Support Programme.