Journal article

Altered inhibition-related frontolimbic connectivity in obsessive-compulsive disorder.

Laura S van Velzen, Stella J de Wit, Branislava Ćurĉić-Blake, Daniëlle C Cath, Froukje E de Vries, Dick J Veltman, Ysbrand D van der Werf, Odile A van den Heuvel

Hum Brain Mapp | Published : 2015

Abstract

BACKGROUND: Recent studies have shown that response inhibition is impaired in patients with obsessive-compulsive disorder and their unaffected siblings, suggesting that these deficits may be considered a cognitive endophenotype of obsessive-compulsive disorder. Structural and functional neural correlates of altered response inhibition have been identified in patients and siblings. This study aims to examine the functional integrity of the response inhibition network in patients with obsessive-compulsive disorder and their unaffected siblings. METHODS: Forty-one unmedicated patients with obsessive-compulsive disorder, 17 of their unaffected siblings and 37 healthy controls performed a stop si..

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