Journal article
Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species
MK Montgomery, SHJ Brown, XY Lim, CE Fiveash, B Osborne, NL Bentley, JP Braude, TW Mitchell, ACF Coster, AS Don, GJ Cooney, C Schmitz-Peiffer, N Turner
Biochimica Et Biophysica Acta Molecular and Cell Biology of Lipids | ELSEVIER SCIENCE BV | Published : 2016
Abstract
In a recent study, we showed that in response to high fat feeding C57BL/6, 129X1, DBA/2 and FVB/N mice all developed glucose intolerance, while BALB/c mice displayed minimal deterioration in glucose tolerance and insulin action. Lipidomic analysis of livers across these five strains has revealed marked strain-specific differences in ceramide (Cer) and sphingomyelin (SM) species with high-fat feeding; with increases in C16-C22 (long-chain) and reductions in C > 22 (very long-chain) Cer and SM species observed in the four strains that developed HFD-induced glucose intolerance. Intriguingly, the opposite pattern was observed in sphingolipid species in BALB/c mice. These strain-specific changes ..
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Awarded by Diabetes Australia Research Trust
Funding Acknowledgements
We thank the Biological Testing Facility at the Garvan Institute and the UNSW Biological Resources Centre (Sydney, Australia) for assistance with animal care. This work was supported by funding from the National Health and Medical Research Council of Australia (NHMRC - 535921), the Diabetes Australia Research Trust, the University of Wollongong and the Australian Research Council (ARC - LE0989078). MKM and GJC are supported by NHMRC Research Fellowships (APP1071143 and APP1107290) and TWM and NT are supported by ARC Future Fellowships (FT110100249 and FT120100371).