Glucagon phosphorylates serine 552 of beta-catenin leading to increased expression of cyclin D1 and c-Myc in the isolated rat liver
Md Kamrul H Chowdhury, Magda K Montgomery, Margaret J Morris, Emmanuelle Cognard, Peter R Shepherd, Greg C Smith
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | TAYLOR & FRANCIS LTD | Published : 2015
In the last 20 years the prevalence of metabolic disorders, in particular type 2 diabetes (T2D), has more than doubled. Recently, a strong link between T2D and cancer, in particularly liver cancer has been reported. However, the mechanism connecting the development of type 2 diabetes and cancer remains unknown. One of the biggest drivers of liver cancer is alterations in the Wnt/β-catenin pathway. In this study, we aimed to identify the effect of glucagon on β-catenin in the isolated rat liver. We found glucagon, which is substantially raised in patients with T2D, rapidly phosphorylates β-catenin on serine 552 that is associated with increased expression of genes cyclin D1 (CCND1) and c-Myc ..View full abstract
This work was supported by the University of New South Wales (UNSW) Australia, PhD stipend (UIPA) of Md. Kamrul Hasan Chowdhury.