Journal article
Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding
MK Montgomery, NL Hallahan, SH Brown, M Liu, TW Mitchell, GJ Cooney, N Turner
Diabetologia | SPRINGER | Published : 2013
Abstract
Aims/hypothesis: Metabolic disorders are commonly investigated using knockout and transgenic mouse models. A variety of mouse strains have been used for this purpose. However, mouse strains can differ in their inherent propensities to develop metabolic disease, which may affect the experimental outcomes of metabolic studies. We have investigated strain-dependent differences in the susceptibility to diet-induced obesity and insulin resistance in five commonly used inbred mouse strains (C57BL/6J, 129X1/SvJ, BALB/c, DBA/2 and FVB/N). Methods: Mice were fed either a low-fat or a high-fat diet (HFD) for 8 weeks. Whole-body energy expenditure and body composition were then determined. Tissues were..
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Funding Acknowledgements
This work was supported by funding from the National Health and Medical Research Council of Australia, the University of Wollongong and the Australian Research Council.