Journal article

An ancient look at UCP1

Martin Klingenspor, Tobias Fromme, David A Hughes, Lars Manzke, Elias Polyrneropoulos, Tobias Riemann, Magdalene Trzcionka, Verena Hirschberg, Martin Jastroch

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | ELSEVIER SCIENCE BV | Published : 2008

Abstract

Brown adipose tissue serves as a thermogenic organ in placental mammals to defend body temperature in the cold by nonshivering thermogenesis. The thermogenic function of brown adipose tissue is enabled by several specialised features on the organ as well as on the cellular level, including dense sympathetic innervation and vascularisation, high lipolytic capacity and mitochondrial density and the unique expression of uncoupling protein 1 (UCP1). This mitochondrial carrier protein is inserted into the inner mitochondrial membrane and stimulates maximum mitochondrial respiration by dissipating proton-motive force as heat. Studies in knockout mice have clearly demonstrated that UCP1 is essentia..

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University of Melbourne Researchers