A Natural History of Actinic Keratosis and Cutaneous Squamous Cell Carcinoma Microbiomes
David LA Wood, Nancy Lachner, Jean-Marie Tan, Stephanie Tang, Nicola Angel, Antonia Laino, Richard Linedale, Kim-Anh Le Cao, Mark Morrison, Ian H Frazer, H Peter Soyer, Philip Hugenholtz
MBIO | AMER SOC MICROBIOLOGY | Published : 2018
Cutaneous squamous cell carcinoma (SCC) is the second-most-common cancer in Australia. The majority of SCCs progress from premalignant actinic keratosis (AK) lesions that form on chronically sun-exposed skin. The role of skin microbiota in this progression is not well understood; therefore, we performed a longitudinal microbiome analysis of AKs and SCCs using a cohort of 13 SCC-prone immunocompetent men. The majority of variability in microbial profiles was attributable to subject, followed by time and lesion type. Propionibacterium and Malassezia organisms were relatively more abundant in nonlesional photodamaged skin than in AKs and SCCs. Staphylococcus was most commonly associated with le..View full abstract
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Awarded by NHMRC
Awarded by NHMRC Career Development Fellowship
This work was funded by NHMRC program grant APP1071822 and NHMRC project grant APP1059012. We acknowledge the generous support of The Merchant Foundation and the Epiderm Foundation. K.-A.L.C. was supported by NHMRC Career Development Fellowship (APP1087415). The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.