Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex
Phan H Truong, Giuseppe D Ciccotosto, Roberto Cappai
NEUROCHEMICAL RESEARCH | SPRINGER/PLENUM PUBLISHERS | Published : 2019
The amyloid precursor protein (APP) is a member of a conserved gene family that includes the amyloid precursor-like proteins 1 (APLP1) and 2 (APLP2). APP and APLP2 share a high degree of similarity, and have overlapping patterns of spatial and temporal expression in the central and peripheral tissues, in particular at the neuromuscular junction. APP-family knockout (KO) studies have helped elucidate aspects of function and functional redundancy amongst the APP-family members. In the present study, we investigated motor performance of APLP2-KO mice and the effect sex differences and age-related changes have on motor performance. APLP2-KO and WT (on C57Bl6 background) littermates control mice ..View full abstract
This study was supported by National Health and Medical Research Council of Australia to RC. PHT was a recipient of a Nancy Frances Curry PhD Scholarship. We thank the School of Biomedical Sciences animal facility staff for assisting with animal care and handling, and the School of Biomedical Sciences Histology Facility for its resources.We thank Paul Kennedy, Alfred Health,for theirassistance with the ATPase stainingprotocol.We thank Prof Sangram Sisodia for the APLP2 knockout mice.