Journal article
Metabolic Biomarkers of Monochorionic Twins Complicated With Selective Intrauterine Growth Restriction in Cord Plasma and Placental Tissue
Lianlian Wang, Ting-Li Han, Xiaofang Luo, Siming Li, Tim Young, Chang Chen, Li Wen, Ping Xu, Yangxi Zheng, Richard Saffery, Philip N Baker, Chao Tong, Hongbo Qi
SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2018
Abstract
The selective intrauterine growth restriction (sIUGR) of monochorionic diamniotic (MCDC) twins causes phenotypic growth discordance, which is correlated with metabolomic pertubations. A global, untargeted identification of the metabolic fingerprint may help elucidate the etiology of sIUGR. Umbilical cord blood and placentas collected from 15 pairs of sIUGR monochorionic twins, 24 pairs of uncomplicated twins, and 14 singletons diagnosed with intrauterine growth restriction (IUGR) were subjected to gas chromatography-mass spectrometry based metabolomic analyses. Supervised multivariate regression analysis and pathway analysis were performed to compare control twins with sIUGR twins. A general..
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Awarded by Ministry of Science and Technology
Awarded by National Natural Sciences Foundation of China
Awarded by Chongqing Municipal Education Commission
Awarded by Chongqing Science and Technology Commission
Awarded by Chongqing Entrepreneurship and Innovation Supporting Program for Returned Overseas Students
Funding Acknowledgements
This work was supported by grants from Ministry of Science and Technology (2018YFC1002901,2016YFC1000407), National Natural Sciences Foundation of China (81520108013, 81771613, 81671488, 81871189), Chongqing Municipal Education Commission (CXTDX201601014), Chongqing Science and Technology Commission (cstc2017jcyjBX0045, cstc2018jcyjAX0216), Chongqing Entrepreneurship and Innovation Supporting Program for Returned Overseas Students (cx2017104). In addition, this study was supported by the "111 program" of the Ministry of Education P.R.C and the State Administration of Foreign Experts Affairs P.R.C., and Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission P.R.C.