Prevalence of Circadian Misalignment and Its Association With Depressive Symptoms in Delayed Sleep Phase Disorder
Jade M Murray, Tracey L Sletten, Michelle Magee, Christopher Gordon, Nicole Lovato, Delwyn J Bartlett, David J Kennaway, Leon C Lack, Ronald R Grunstein, Steven W Lockley, Shantha MW Rajaratnam
Sleep | OXFORD UNIV PRESS INC | Published : 2017
Study Objective: To examine the prevalence of circadian misalignment in clinically diagnosed delayed sleep phase disorder (DSPD) and to compare mood and daytime functioning in those with and without a circadian basis for the disorder. Methods: One hundred and eighty-two DSPD patients aged 16-64 years, engaged in regular employment or school, underwent sleep-wake monitoring in the home, followed by a sleep laboratory visit for assessment of salivary dim light melatonin onset (DLMO). Based on the DLMO assessments, patients were classified into two groups: circadian DSPD, defined as DLMO occurring at or after desired bedtime (DBT), or non-circadian DSPD, defined as DLMO occurring before DBT. Re..View full abstract
The study was funded by a research grant from the National Health and Medical Research Council (NHMRC) to SMWR, SWL, RRG, LCL, and DJK, and research support from Philips Respironics and the NHMRC Australasian Sleep Trials Network. JMM was supported by an Australian Postgraduate Award from Monash University and PhD top-up scholarship from the Cooperative Research Centre for Alertness, Safety and Productivity. RRG is supported by an NHMRC Practitioner Fellowship. The sponsors provided unrestricted research grants. The sponsors had no role in any other aspects of the study.