Diagnosis, Cause, and Treatment Approaches for Delayed Sleep-Wake Phase Disorder
Michelle Magee, Emily M Marbas, Kenneth P Wright, Shantha MW Rajaratnam, Josiane L Broussard
Sleep Medicine Clinics | ELSEVIER INC | Published : 2016
Delayed sleep-wake phase disorder (DSWPD) is commonly defined as an inability to fall asleep and wake at societal times resulting in excessive daytime sleepiness. Although the cause is multifaceted, delays in sleep time are largely driven by misalignment between the circadian pacemaker and the desired sleep-wake timing schedule. Current treatment approaches focus on correcting the circadian delay; however, there is a lack of data investigating combined therapies for treatment of DSWPD.
M. Magee and E. Marbas report no conflicts of interest. K.P. Wright, Jr, reports grants from National Institutes of Health and the Office of Naval Research and Philips Inc, and personal fees from the American College of Chest Physicians, The Obesity Society, the Obesity Medicine Association, and Torvec, Inc during the preparation of this work. He has also served as a consultant for Takeda Pharmaceuticals North America. S.W.M. Rajaratnam has served as a consultant through his institution to Vanda Pharmaceuticals, Philips Respironics, EdanSafe, The Australian Workers' Union, National Transport Commission, and Transport Accident Commission, and has through his institution received research grants and/or unrestricted educational grants from Vanda Pharmaceuticals, Takeda Pharmaceuticals North America, Philips Lighting, Philips Respironics, Cephalon, and ResMed Foundation, and reimbursements for conference travel expenses from Vanda Pharmaceuticals. His institution has received equipment donations or other support from Optalert, Compumedics, and Tyco Healthcare. He has also served as an expert witness and/or consultant to shift work organizations. S.W.M. Rajaratnam also serves as a program leader in the Cooperative Research Centre for Alertness, Safety and Productivity. J.L. Broussard reports no conflicts of interest.