A lipidated bi-epitope vaccine comprising of MHC-I and MHC-II binder peptides elicits protective CD4 T cell and CD8 T cell immunity against Mycobacterium tuberculosis
Pradeep K Rai, Sathi Babu Chodisetti, Sudeep K Maurya, Sajid Nadeem, Weiguang Zeng, Ashok K Janmeja, David C Jackson, Javed N Agrewala
JOURNAL OF TRANSLATIONAL MEDICINE | BMC | Published : 2018
BACKGROUND: The clinical trials conducted at Chingleput India suggest that BCG fails to protect against tuberculosis (TB) in TB-endemic population. Recent studies advocate that non-tuberculous mycobacteria and latent Mycobacterium tuberculosis (Mtb) infection interferes in the antigen processing and presentation of BCG in inducing protective immunity against Mtb. Thereby, indicating that any vaccine that require extensive antigen processing may not be efficacious in TB-endemic zones. Recently, we have demonstrated that the vaccine candidate L91, which is composed of lipidated promiscuous MHC-II binder epitope, derived from latency associated Acr1 antigen of Mtb is immunogenic in the murine a..View full abstract
Awarded by Council of Scientific and Industrial Research
Awarded by Department of Biotechnology (DBT Indo-Australian Grant), New Delhi, India
This work was funded by the Council of Scientific and Industrial Research (OLP-0088) and Department of Biotechnology (DBT Indo-Australian Grant GAP 103) New Delhi, India. PKR, SBC, SKM are recipient of fellowships of CSIR and SN of DBT, New Delhi.