Journal article

Alcohol consumption is associated with widespread changes in blood DNA methylation: analysis of cross-sectional and longitudinal data

Pierre-Antoine Dugué, Rory Wilson, Benjamin Lehne, Harindra Jayasekara, Xiaochuan Wang, Chol-Hee Jung, JiHoon Joo, Enes Makalic, Daniel Schmidt, Laura Baglietto, Gianluca Severi, Christian Gieger, Karl-Heinz Ladwig, Annette Peters, Jaspal Kooner, Melissa Southey, Dallas English, Melanie Waldenberger, John Chambers, Graham Giles Show all

Published : 2018

Abstract

ABSTRACT Background: DNA methylation may be one of the mechanisms by which alcohol consumption is associated with the risk of disease. We conducted a large-scale, cross-sectional, genome-wide DNA methylation association study of alcohol consumption and a longitudinal analysis of repeated measurements taken several years apart. Methods: Using the Illumina Infinium HumanMethylation450 BeadChip, DNA methylation measures were determined using baseline peripheral blood samples from 5,606 adult Melbourne Collaborative Cohort Study (MCCS) participants. For a subset of 1,088 of them, these measures were repeated using blood samples collected at follow-up, a median of 11 years later. Associations bet..

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