Application of autologous bone marrow derived mesenchymal stem cells to an ovine model of growth plate cartilage injury.
Rosa C McCarty, Cory J Xian, Stan Gronthos, Andrew CW Zannettino, Bruce K Foster
Open Orthopaedics Journal | Published : 2010
Injury to growth plate cartilage in children can lead to bone bridge formation and result in bone growth deformities, a significant clinical problem currently lacking biological treatment. Mesenchymal stem/stromal cells (MSC) offer a promising therapeutic option for regeneration of damaged cartilage, due to their self renewing and multi-lineage differentiation attributes. Although some small animal model studies highlight the therapeutic potential of MSC for growth plate repair, translational research in large animal models, which more closely resemble the human condition, are lacking. Our laboratory has recently characterised MSCs derived from ovine bone marrow, and demonstrated these cells..View full abstract