Anaemia in Acute HIV-1 Subtype C Infection
Koleka Mlisana, Sara C Auld, Anneke Grobler, Francois van Loggerenberg, Carolyn Williamson, Itua Iriogbe, Magdalena E Sobieszczyk, Salim Safurdeen Abdool Karim
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2008
BACKGROUND: The high prevalence of anaemia and the increased morbidity and mortality associated with anaemia during AIDS has been well described yet there has been little information about anaemia and changes in haemoglobin levels during acute and early HIV-1 infection. METHODS: HIV-negative women (n = 245) were enrolled into an observational cohort as part of the Centre for the AIDS Programme of Research in South Africa (CAPRISA) Acute Infection Study. Acute infection was diagnosed following a positive HIV RNA PCR in the absence of antibodies, or detection of HIV-1 antibodies within 3 months of a previously negative antibody test. Haemotologic parameters were assessed before infection and a..View full abstract
Awarded by Centre for the AIDs Programme of Research in South Africa (CAPRISA)
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
This study was funded by the Centre for the AIDs Programme of Research in South Africa (CAPRISA). CAPRISA is part of the Comprehensive International Program of Research on AIDS (CIPRA) and is supported by the National Institute of Allergy and Infectious Disease (NIAID), National Institutes of Health (NIH) and the US Department of Health and Human Services (DHHS)(grant# AI51794). The funders approved the design of the study and provided monitoring oversight thoughout the conduct of the study. The funders were not involved in the collection, analysis of data or in the preparation, review or approval of the manuscript.