Placental Ras Regulates Inflammation Associated with Maternal Obesity
Stella Liong, Gillian Barker, Martha Lappas
MEDIATORS OF INFLAMMATION | HINDAWI LTD | Published : 2018
Heightened placental inflammation and dysfunction are commonly associated in pregnant obese women compared to their pregnant lean counterparts. The small GTPase superfamily members known as the rat sarcoma viral oncogene homolog (Ras) proteins, in particular, the K-Ras and H-Ras isoforms, have been implicated to regulate inflammation. The aims were to determine the placental Ras expression and activity with maternal obesity and its role in regulating placental inflammation. Human placenta was obtained at term Caesarean section from lean and obese pregnant women to determine the effect of maternal obesity on Ras protein expression and activity. To determine the effect of Ras on inflammation i..View full abstract
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Awarded by National Health and Medical Research Council
The following are gratefully acknowledged: the clinical research midwives Genevieve Christophers, Gabrielle Pell, and Rachel Murdoch for sample collection, and the Obstetrics and Midwifery staff of the Mercy Hospital for Women for their cooperation. Associate Professor Martha Lappas is supported by Fellowships from the National Health and Medical Research Council (Career Development Fellowship grant no. 1047025) and University of Melbourne (MDHS Research Fellowship). Dr. Stella Liong is a recipient of the Glyn White Research Fellowship by the Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) Research Foundation, an Early Career Researcher Fellowship by the University of Melbourne, and a Postdoctoral Award by the Endocrine Society of Australia (ESA). Funding for this study was provided by the Norman Beischer Medical Research Foundation, the University of Melbourne, and the Mercy Research Foundation.