The signalling conformation of the insulin receptor ectodomain
Felix Weis, John G Menting, Mai B Margetts, Shu Jin Chan, Yibin Xu, Norbert Tennagels, Paulus Wohlfart, Thomas Langer, Christoph W Mueller, Matthias K Dreyer, Michael C Lawrence
Nature Communications | NATURE PUBLISHING GROUP | Published : 2018
Awarded by Australian National Health and Medical Research Council (NHMRC)
Awarded by National Institutes of Health
Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
M.C.L. acknowledges financial support from the Australian National Health and Medical Research Council (NHMRC) Project Grants APP1099595 and APP1128553; his Institute receives Victorian State Government Operational Infrastructure Support and funding from the Australian NHMRC Independent Research Institutes Infrastructure Support Scheme. S.J.C. acknowledges financial support from the National Institutes of Health grants DK013914 and UC DRTC DK020595. We thank Mr John Bentley (CSIRO, Australia) for assistance with the preparation of the bis-BOC-insulin-affinity resin, Mr Peter Hoyne (CSIRO, Australia) for advice regarding the production of IR Delta beta-zip, and Prof. Ken Siddle (University of Cambridge, England) for providing the hybridomas expressing mAb 83-7. This manuscript is dedicated to our late colleagues Dr Colin Ward and Professor Donald Steiner, who instigated independent aspects of the work described here.