A Task Force Against Local Inflammation and Cancer: Lymphocyte Trafficking to and Within the Skin
Fanny Lafouresse, Joanna R Groom
FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2018
The skin represents a specialized site for immune surveillance consisting of resident, inflammatory and memory populations of lymphocytes. The entry and retention of T cells, B cells, and ILCs is tightly regulated to facilitate detection of pathogens, inflammation and tumors cells. Loss of individual or multiple populations in the skin may break tolerance or increase susceptibility to tumor growth and spread. Studies have significantly advanced our understanding of the role of skin T cells and ILCs at steady state and in inflammatory settings such as viral challenge, atopy, and autoimmune inflammation. The knowledge raised by these studies can benefit to our understanding of immune cell traf..View full abstract
Awarded by Australian Research Council Future Fellowship
FL is supported by a Walter and Eliza Hall Centenary Fellowship sponsored by CSL. JG is supported by Australian Research Council Future Fellowship (FT130100708). This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS.