Mathematical modelling of vancomycin-resistant enterococci transmission during passive surveillance and active surveillance with contact isolation highlights the need to identify and address the source of acquisition
Agnes Loo Yee Cheah, Allen C Cheng, Denis Spelman, Roger L Nation, David CM Kong, Emma S McBryde
BMC INFECTIOUS DISEASES | BMC | Published : 2018
BACKGROUND: Clinical studies and mathematical simulation suggest that active surveillance with contact isolation is associated with reduced vancomycin-resistant enterococci (VRE) prevalence compared to passive surveillance. Models using pre- and post-intervention data that account for the imperfect observation and serial dependence of VRE transmission events can better estimate the effectiveness of active surveillance and subsequent contact isolation; however, such analyses have not been performed. METHODS: A mathematical model was fitted to surveillance data collected pre- and post-implementation of active surveillance with contact isolation in the haematology-oncology ward. We developed a ..View full abstract
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Awarded by NHMRC
ESM was funded by an NHMRC Career Development Fellowship (1034464). AC was funded by an NHMCRC Career Development Fellowship (1068732). There was no funding for the direct project costs of the study.