Journal article
Mediterranean diet adherence and rate of cerebral Aβ-amyloid accumulation: Data from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing
SR Rainey-Smith, Y Gu, SL Gardener, JD Doecke, VL Villemagne, BM Brown, K Taddei, SM Laws, HR Sohrabi, M Weinborn, D Ames, C Fowler, SL Macaulay, P Maruff, CL Masters, O Salvado, CC Rowe, N Scarmeas, RN Martins
Translational Psychiatry | SPRINGERNATURE | Published : 2018
Abstract
Accumulating research has linked Mediterranean diet (MeDi) adherence with slower cognitive decline and reduced Alzheimer’s disease (AD) risk. However, no study to-date has examined the relationship between MeDi adherence and accumulation of cerebral Aβ-amyloid (Aβ; a pathological hallmark of AD) in older adults. Cognitively normal healthy control participants of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Ageing completed the Cancer Council of Victoria Food Frequency Questionnaire at baseline, which was used to construct a MeDi score for each participant (score range 0–9; higher score indicating higher adherence). Cerebral Aβ load was quantified by Pittsburgh Compound B ..
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Funding Acknowledgements
Funding for the study was provided by CSIRO, Edith Cowan University, The Florey Institute of Neuroscience and Mental Health, Alzheimer's Australia, National Ageing Research Institute, Austin Health, CogState Ltd., and Hollywood Private Hospital. The authors wish to thank both the participants of the AIBL Study (www.aibl.csiro.au) for their commitment and dedication to helping advance research into the early detection and causation of AD, and the clinicians who referred patients to the study.