Transcriptomic Resources for Parasitic Nematodes of Veterinary Importance
Aaron R Jex, Robin B Gasser, Erich M Schwarz
TRENDS IN PARASITOLOGY | ELSEVIER SCI LTD | Published : 2019
Parasitic nematodes are important pathogens of animals, causing diseases that impact on agricultural production worldwide. Research on these worms has been constrained by a lack of genetic and genomic tools. Nonetheless, over the past decade this field has made substantial advances, many of which have been led by transcriptomic sequencing. The present review summarises major transcriptomic studies of veterinary parasitic nematodes in recent years, and comments on overarching themes stemming from this work that inform our understanding of parasitism. Finally, we comment on current, state-of-the-art informatic tools for the analysis of complex worm transcriptomes to extract maximum the molecul..View full abstract
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Awarded by Australian Research Council
Awarded by Australian National Health and Medical Research Funding (NHMRC)
The authors wish to acknowledge the many research groups and scientists that have developed the transcriptomic studies for parasitic nematodes underpinning this review, the bioinformaticians who have made their analytical tools and software freely available in open-source format, and the large teams of scientists who have developed, curated, and maintained the genetic data repositories (such as NCBI's SRA and Wormbase ParaSite) that make these data accessible to the global research community. A.R. Jex acknowledges funding from the Australian Research Council (DP180102049) and Australian National Health and Medical Research Funding (NHMRC Career Development Fellowship APP1126935). A.R. Jex also acknowledges funding from the Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council Independent Research Institute Infrastructure Support Scheme. R.B. Gasser's research is supported predominantly by the Australian Research Council, the National Health and Medical Research Council, Melbourne Water Corporation and Yourgene Bioscience. E.M. Schwarz acknowledges start-up funding support from Cornell University.