Failure of Autophagy-Lysosomal Pathways in Rod Photoreceptors Causes the Early Retinal Degeneration Phenotype Observed in Cln6(nclf) Mice

Philipp von Eisenhart-Rothe; Alexandra Grubman; Ursula Greferath; Linda J Fothergill; Andrew Jobling; Joanna A Phipps; Anthony R White; Erica L Fletcher; Kirstan A Vessey

Journal article

Failure of Autophagy-Lysosomal Pathways in Rod Photoreceptors Causes the Early Retinal Degeneration Phenotype Observed in Cln6(nclf) Mice

Philipp von Eisenhart-Rothe, Alexandra Grubman, Ursula Greferath, Linda J Fothergill, Andrew Jobling, Joanna A Phipps, Anthony R White, Erica L Fletcher, Kirstan A Vessey

Investigative Ophthalmology & Visual Science | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2018

DOI: 10.1167/iovs.18-24757

University of Melbourne Researchers

Andrew Jobling Author Anatomy and Physiology

Erica Fletcher Author Anatomy and Physiology

Una Greferath Author Anatomy and Physiology

Kirstan Vessey Author Anatomy and Physiology

Linda Fothergill Author Anatomy and Physiology

Related Projects (6)

A novel mechanism and treatment strategy for age-related macular degeneration

NOVEL MECHANISMS OF EARLY AGE RELATED MACULAR DEGENERATION

Age Related Macular degeneration (AMD) is a leading cause of blindness in Australia. In this project we will examine a novel mechanism by wh..

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Targeting monocyte phagocytosis to reduce progression of age relate macular degeneration

THE ROLE OF REDUCED PHAGOCYTOSIS IN THE PATHOGENESIS OF AGE-RELATED MACULAR DEGENERATION

Understanding the underlying mechanisms which lead to age-related macular degeneration (AMD) is critical if we are to ultimately develop nov..

Grants

Awarded by National Health & Medical Research Council of Australia

Awarded by Rebecca L. Cooper Medical Research Foundation

Funding Acknowledgements

Supported by the National Health & Medical Research Council of Australia Project Grant APP1138253 (ELF/KAV) and the Rebecca L. Cooper Medical Research Foundation APP10789 (KAV).