Journal article

Epigenetic Aging in Major Depressive Disorder

Laura KM Han, Moji Aghajani, Shaunna L Clark, Robin F Chan, Mohammad W Hattab, Andrey A Shabalin, Min Zhao, Gaurav Kumar, Lin Ying Xie, Rick Jansen, Yuri Milaneschi, Brian Dean, Karolina A Aberg, Edwin JCG van den Oord, Brenda WJH Penninx

AMERICAN JOURNAL OF PSYCHIATRY | AMER PSYCHIATRIC PUBLISHING, INC | Published : 2018

Abstract

OBJECTIVE: Major depressive disorder is associated with an increased risk of mortality and aging-related diseases. The authors examined whether major depression is associated with higher epigenetic aging in blood as measured by DNA methylation (DNAm) patterns, whether clinical characteristics of major depression have a further impact on these patterns, and whether the findings replicate in brain tissue. METHOD: DNAm age was estimated using all methylation sites in blood of 811 depressed patients and 319 control subjects with no lifetime psychiatric disorders and low depressive symptoms from the Netherlands Study of Depression and Anxiety. The residuals of the DNAm age estimates regressed on ..

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Grants

Awarded by Geestkracht program of the Netherlands Organization for Health Research and Development (Zon-MW)


Awarded by NIMH


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Awarded by NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM


Funding Acknowledgements

The Netherlands Study of Depression and Anxiety (www.nesda.nl) is funded through the Geestkracht program of the Netherlands Organization for Health Research and Development (Zon-MW, grant 10-000-1002) and participating universities and mental health care organizations (VU University Medical Center, GGZ in Geest, Arkin, Leiden University Medical Center, GGZ Rivierduinen, University Medical Center Groningen, Lentis, GGZ Friesland, GGZ Drenthe). This work was supported by NIMH grant R01MH099110 and the EMGO+ Travel Grant. Brain tissue was received from four brain banks: the Victorian Brain Bank, supported by the Florey Institute of Neuroscience and Mental Health and the Alfred and Victorian Forensic Institute of Medicine and funded by Australia's National Health and Medical Research Council and Parkinson's Victoria; the Stanley Medical Research Institute; the Netherlands Brain Bank, Netherlands Institute of Neuroscience, Amsterdam; and the Harvard Brain Tissue Resource Center.Dr. Penninx has received research funding from Janssen Research and Boehringer Ingelheim. The other authors report no financial relationships with commercial interests.