Translational review: Neuroimmune mechanisms in cough and emerging therapeutic targets
Alice E McGovern, Kirsty R Short, Aung Aung Kywe Moe, Stuart B Mazzone
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | MOSBY-ELSEVIER | Published : 2018
Cough is an essential defensive behavior for maintaining airway patency and to protect the lungs from potentially harmful agents. However, inflammatory pathologies can sensitize and activate the neural pathways regulating cough, leading to excessive and nonproductive coughing that serves little protective utility. Problematic cough continues to be one of the most common reasons for seeking medical advice, yet for many patients, it can be refractory to disease-specific treatments and currently available antitussive therapies. The effect of inflammation on cough neural processing occurs not only at the level of the bronchopulmonary sensory nerve terminals but also within the nervous system at ..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Awarded by Australian Research Council DECRA Fellowship
S.B.M. and A.E.M. are funded by the National Health and Medical Research Council of Australia (project grant GNT1078943 and Fellowship award GNT1121376). K.R.S. holds an Australian Research Council DECRA Fellowship (DE180100512).