Journal article

Persistent negative symptoms in individuals at Ultra High Risk for psychosis

Alison R Yung, Barnaby Nelson, Patrick D McGorry, Stephen J Wood, Ashleigh Lin

SCHIZOPHRENIA RESEARCH | ELSEVIER SCIENCE BV | Published : 2019

Abstract

Persistent negative symptoms (PNS) defined as negative symptoms that persist for at least six months in the absence of high levels of positive, depressive and extrapyramidal symptoms, are evident early in the course of schizophrenia from the first episode of psychosis. However, their presence even earlier in the illness, in those at Ultra High Risk of psychosis, has not been investigated. In this study, we examined the prevalence, baseline correlates and outcome of PNS in 363 Ultra High Risk individuals. Assessments were conducted at baseline and 2-14 years later (mean follow up time 7.4 years). Baseline assessments included demographic, clinical and neurocognitive measures, which were repea..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) Program


Awarded by NHMRC


Awarded by Medical Research Council


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) Program grants 350241 and 566529 held by Drs Yung, McGorry and Wood; and the Colonial Foundation. Dr. Yung was supported by an NHMRC Senior Research Fellowship (566593) and an NHMRC Principal Research Fellowship (1136829); Dr Nelson was supported by an NHMRC Career Development Fellowship (1027532) and Senior Research Fellowship (1137687), Dr. Wood by an NHMRC Clinical Career Developmental Award (359223) and Medical Research Council grant (MR/K013599/1). Dr. Lin was supported by an NHMRC Career Development Fellowship (1148793).