Journal article

Investigating the Mechanical Properties of Biological Brain Cells With Atomic Force Microscopy

Tariq Mohana Bahwini, Yongmin Zhong, Chengfan Gu, Zeyad Nasa, Denny Oetomo

Journal of Medical Devices | American Society of Mechanical Engineers | Published : 2018

Abstract

Characterization of cell mechanical properties plays an important role in disease diagnoses and treatments. This paper uses advanced atomic force microscopy (AFM) to measure the geometrical and mechanical properties of two different human brain normal HNC-2 and cancer U87 MG cells. Based on experimental measurement, it measures the cell deformation and indentation force to characterize cell mechanical properties. A fitting algorithm is developed to generate the force-loading curves from experimental data. An inverse Hertzian method is also established to identify Young's moduli for HNC-2 and U87 MG cells. The results demonstrate that Young's modulus of cancer cells is different from that of ..

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University of Melbourne Researchers

Grants

Funding Acknowledgements

This work was supported by the Ministry of Education in Saudi Arabia via the Ph.D. scholarship of the first author.