ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity
Taisuke Nakahama, Yuki Kato, Jung In Kim, Tuangtong Vongpipatana, Yutaka Suzuki, Carl R Walkley, Yukio Kawahara
EMBO reports | WILEY | Published : 2018
Awarded by Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
We thank Drs. K. Nishikura (The Wistar Institute) and O. Takeuchi (Kyoto University) for providing A1<SUP>fl/fl</SUP> mice and Cd4<SUP>cre</SUP> mice, respectively. We thank Drs K. Takeda, H. Kayama, and I. Chinen for technical advice and all the staff in the Center for Medical Research and Education, Graduate School of Medicine, Osaka University, for technical support. Computations were partially performed on the NIG Supercomputer at ROIS National Institute of Genetics, Japan. This work was supported by Grants-in-Aid KAKENHI (25293201, 25110719, and 16H06279 to Y. Kawahara; 18K15186, 16H06279, 15K19126, and 255768 to T.N.; and 18K11526 and 15K00401 to Y. Kato) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan and by grants from the Takeda Science Foundation, the SENSHIN Medical Research Foundation, and the Mochida Memorial Foundation for Medical and Pharmaceutical Research (to Y. Kawahara), Nagao Memorial Fund (to T.N.), and Victorian Cancer Agency Mid-Career Fellowship (to C.R.W.).