Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History
Heather J Fullerton, Nicholas Stence, Nancy K Hills, Bin Jiang, Catherine Amlie-Lefond, Timothy J Bernard, Neil R Friedman, Rebecca Ichord, Mark T Mackay, Mubeen F Rafay, Stephane Chabrier, Maja Steinlin, Mitchell SV Elkind, Gabrielle A deVeber, Max Wintermark
STROKE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018
Background and Purpose- Focal cerebral arteriopathy (FCA)-a common cause of arterial ischemic stroke in previously healthy children-often progresses over days to weeks, increasing the risk of recurrent stroke. We developed a novel severity scoring system designed to quantify FCA progression and correlate with clinical outcomes. Methods- The VIPS study (Vascular Effects of Infection in Pediatric Stroke) prospectively enrolled 355 children with arterial ischemic stroke (2010-2014), including 41 with centrally confirmed FCA. Two neuroradiologists independently reviewed FCA cerebrovascular imaging, assigning a graded severity score of zero (no involvement) to 4 (occlusion) to individual arterial..View full abstract
Awarded by National Institutes of Health
Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
This study was supported by National Institutes of Health grant R01 NS062820 (principal investigators Drs Fullerton and DeVeber), statistical support by Marc and Lynne Benioff, and by American Heart Association Bugher Award (Dr Bernard).