Journal article

Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History

Heather J Fullerton, Nicholas Stence, Nancy K Hills, Bin Jiang, Catherine Amlie-Lefond, Timothy J Bernard, Neil R Friedman, Rebecca Ichord, Mark T Mackay, Mubeen F Rafay, Stephane Chabrier, Maja Steinlin, Mitchell SV Elkind, Gabrielle A deVeber, Max Wintermark



Background and Purpose- Focal cerebral arteriopathy (FCA)-a common cause of arterial ischemic stroke in previously healthy children-often progresses over days to weeks, increasing the risk of recurrent stroke. We developed a novel severity scoring system designed to quantify FCA progression and correlate with clinical outcomes. Methods- The VIPS study (Vascular Effects of Infection in Pediatric Stroke) prospectively enrolled 355 children with arterial ischemic stroke (2010-2014), including 41 with centrally confirmed FCA. Two neuroradiologists independently reviewed FCA cerebrovascular imaging, assigning a graded severity score of zero (no involvement) to 4 (occlusion) to individual arterial..

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